Hadrat Abdullah bin Masud (r.a.) reported: ‘The Messenger of Allah (saws) used to supplicate: "Allahumma inni as'alukal-huda, wat-tuqa, wal-afafa, wal-ghina (O Allah! I beseech You for guidance, piety, chastity and contentment)."
Related by Muslim. quoted from Riyad-us-Saliheen (Hadith # 1468)
The Messenger of Allah (saws) preferred to make supplications which were short and general in nature, but wholesome and comprehensive in its meanings.
Huda: Guidance towards virtue, ability to do good deeds, and remain steadfast on the Straight Path of Allah Subhanah.
Tuqa: To comply wholeheartedly with the Commands of Allah and to prevent oneself from what the Lord has forbidden is ‘taqwa’ (piety, or the fear of Allah).
Afafa: means prevention from sins and also means evasion from seeking help from others.
Ghina: enough sustenance which makes one independent of all others except Allah Subhanah.